In Dublin and New York of the 19th century, the brewing business of the wealthiest Guinness clan is thriving. The head of the family, Benjamin Guinness, who is responsible for the success of the business, passes away. Now, his four adult children - Arthur, Edward, Ann, and Ben - must uphold the company's legacy. However, their father's strong will continues to influence the heirs even after his death, leading to many intertwined tragedies.